Isaac
BossRebirthUnlock unknown
Encounter details
- Game ID
- 102
- Environment
- Boss / Cathedral / The Void
- Description
- Isaac is the boss of the Cathedral, and the final boss of Ending 13.
How do you unlock Isaac?
Needs researchNo validated unlock requirement has been imported yet.
Isaac is the boss of the Cathedral, and the final boss of Ending 13.
What unlocking Isaac leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13