2 of Spades
CardRebirthUnlocked
How do you unlock 2 of Spades?
Verified starting unlockSource data confirms that no unlock is required.
Doubles Isaac's Keys. If he has no keys, gives him 2 instead.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking 2 of Spades leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13