Ace of Spades
CardAfterbirth+Locked
How do you unlock Ace of Spades?
In The Binding of Isaac, Ace of Spades is unlocked by unlocking It's the Key.
Structured pathSource-backed requirements are mapped into trackable steps.
Turns all pickups, trinkets and chests in the room into Keys. All non-boss enemies in the room are also transformed into keys.
How to unlock: Defeat The Lamb without taking Hearts, Coins, or Bombs through the entire run
What unlocking Ace of Spades leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13