II - The High Priestess
CardRebirthUnlocked
How do you unlock II - The High Priestess?
Verified starting unlockSource data confirms that no unlock is required.
Mom's dismembered leg stomps on the enemy with the most health, dealing 300 damage and destroying obstacles in the area. If used in an empty room or during the Mom fight, stomps Isaac instead. Isaac can move to avoid the stomp.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking II - The High Priestess leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13