III - The Empress
CardRebirthUnlocked
How do you unlock III - The Empress?
Verified starting unlockSource data confirms that no unlock is required.
Triggers the Whore of Babylon effect (+1.5 Damage, +0.3 Speed) for the current room, regardless of Isaac's total health.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking III - The Empress leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13