Bloody Mary

ChallengeRepentanceLocked

Challenge details

Challenge number: 37
Description: Bloody Mary is challenge #37. Bethany is the starting character for this challenge, and she starts with Blood Bag, Blood Oath, Anemic, Child's Heart, and The Book of Belial. The goal is to defeat Satan. This challenge is unlocked by unlocking Bethany, Blood Bag and It Lives!.

How do you unlock Bloody Mary?

In The Binding of Isaac, Bloody Mary is unlocked by unlocking Bethany (Achievement), unlocking Blood Bag (Achievement), and unlocking It Lives! (Achievement).

Structured pathSource-backed requirements are mapped into trackable steps.

Bloody Mary is challenge #37. Bethany is the starting character for this challenge, and she starts with Blood Bag, Blood Oath, Anemic, Child's Heart, and The Book of Belial. The goal is to defeat Satan. This challenge is unlocked by unlocking Bethany, Blood Bag and It Lives!.

See the full unlock path for Bloody Mary — 5 steps

Bloody Mary (Achievement)
- All of
  - Bethany (Achievement)
    How to unlock: Defeat Mom's Heart or It Lives! on hard mode as Lazarus, without dying at all
  - Blood Bag (Achievement)
    How to unlock: Use the Blood Donation Machine 30 times
  - It Lives! (Achievement)

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What unlocking Bloody Mary leads to

Sigil of Baphomet

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13