BRAINS!
ChallengeAfterbirthLocked
Challenge details
- Challenge number
- 27
- Description
- BRAINS! is Challenge #27, added in The Binding of Isaac: Afterbirth. This challenge is played as ??? and you start blindfolded, with 3 Bob's Brain, Thunder Thighs and the Bob transformation. The goal is to defeat ???. Treasure Rooms do not spawn in this Challenge.
How do you unlock BRAINS!?
In The Binding of Isaac, BRAINS! is unlocked by unlocking BRAINS! (Achievement).
Structured pathSource-backed requirements are mapped into trackable steps.
BRAINS! is Challenge #27, added in The Binding of Isaac: Afterbirth. This challenge is played as ??? and you start blindfolded, with 3 Bob's Brain, Thunder Thighs and the Bob transformation. The goal is to defeat ???. Treasure Rooms do not spawn in this Challenge.
How to unlock: Defeat Isaac 5 times
What unlocking BRAINS! leads to
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13