High Brow

ChallengeRebirthUnlock unknown

Challenge details

Challenge number: 2
Description: High Brow is challenge #2. Isaac begins this challenge with Number One, E. Coli, Butt Bombs, Flush!, and Petrified Poop. The goal is to defeat Mom. This challenge is unlocked by default.

How do you unlock High Brow?

Needs researchNo validated unlock requirement has been imported yet.

High Brow is challenge #2. Isaac begins this challenge with Number One, E. Coli, Butt Bombs, Flush!, and Petrified Poop. The goal is to defeat Mom. This challenge is unlocked by default.

This path has not yet been revealed

This requirement hasn't been imported yet.

View source

What unlocking High Brow leads to

Rune of Jera

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13