Adrenaline
ItemAfterbirth+Unlocked
passiveGame ID 493★★★★
How do you unlock Adrenaline?
Verified starting unlockSource data confirms that no unlock is required.
Increases damage based on how many empty Red Heart containers Isaac has.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Adrenaline leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13