Anemic
ItemRebirthUnlocked
passiveGame ID 214★★★★
How do you unlock Anemic?
Verified starting unlockSource data confirms that no unlock is required.
After Isaac is damaged, a trail of red creep will be left behind him until he leaves the current room. [Before Repentance] +5 range. [Repentance] +1.5 range.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Anemic leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13