Blood Puppy

ItemRepentanceLocked

familiarGame ID 565★★★★

How do you unlock Blood Puppy?

In The Binding of Isaac, Blood Puppy is unlocked by earning the Mother completion mark as Lilith (Character).

Structured pathSource-backed requirements are mapped into trackable steps.

Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac. Dealing enough damage to it returns it to normal.

See the full unlock path for Blood Puppy — 7 steps

Blood Puppy (Achievement)
- Lilith (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Lilith (Character)

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What unlocking Blood Puppy leads to

Nothing depends on this yet.

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13