Box of Spiders
ItemRebirthUnlocked
activeGame ID 288★★★★
How do you unlock Box of Spiders?
Verified starting unlockSource data confirms that no unlock is required.
Spawns [Before Repentance] 1-4 / [Repentance] 4-8 Blue Spiders where Isaac is standing.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Box of Spiders leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13