Breath of Life
ItemRebirthUnlocked
activeGame ID 326★★★★
How do you unlock Breath of Life?
Verified starting unlockSource data confirms that no unlock is required.
Grants a brief moment of invincibility when the charge bar hits zero. Isaac begins taking damage if the item is held any longer. [Repentance] Isaac creates beams of light when touching enemies while invulnerable, and creates a powerful 4-way beam if blocking damage exactly as the invincibility starts.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Breath of Life leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13