Caffeine Pill
ItemRebirthUnlocked
passiveGame ID 340★★★★
How do you unlock Caffeine Pill?
Verified starting unlockSource data confirms that no unlock is required.
Grants +0.3 speed, reduces Isaac's size, and gives a random pill.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Caffeine Pill leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13