Cancer
ItemRebirthUnlocked
passiveGame ID 301★★★★
How do you unlock Cancer?
Verified starting unlockSource data confirms that no unlock is required.
Adds 3 Soul Hearts. Grants The Wafer effect for the current room after taking damage.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Cancer leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13