Depression
ItemAfterbirth+Unlocked
familiarGame ID 469★★★★
How do you unlock Depression?
Verified starting unlockSource data confirms that no unlock is required.
Spawns a familiar that leaves a trail of creep that damages enemies at 6 damage per second. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Depression leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13