E. Coli
ItemRebirthUnlocked
passiveGame ID 236★★★★
How do you unlock E. Coli?
Verified starting unlockSource data confirms that no unlock is required.
Enemies that touch Isaac are transformed into Poop.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking E. Coli leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13