Guillotine
ItemRebirthLocked
familiarGame ID 206★★★★
How do you unlock Guillotine?
In The Binding of Isaac, Guillotine is unlocked by earning the Isaac completion mark as Judas (Character).
Structured pathSource-backed requirements are mapped into trackable steps.
Isaac's head becomes an orbital familiar that blocks shots and deals contact damage. Tears are still fired from the rotating head. [Before Repentance] +1 damage, -1 tear delay. [Repentance] +1 damage, +0.5 fire rate.
See the full unlock path for Guillotine — 5 stepsWhat unlocking Guillotine leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13