Guppy's Head
ItemRebirthUnlocked
activeGame ID 145★★★★
How do you unlock Guppy's Head?
Verified starting unlockSource data confirms that no unlock is required.
Spawns 2-4 friendly Blue Flies that damage enemies.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Guppy's Head leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13