Infestation
ItemRebirthUnlocked
passiveGame ID 148★★★★
How do you unlock Infestation?
Verified starting unlockSource data confirms that no unlock is required.
[Before Repentance] 1-3 Blue Flies randomly spawn every time Isaac gets hit. / [Repentance] 2-6 Blue Flies randomly spawn every time Isaac gets hit.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Infestation leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13