Infestation 2
ItemRebirthUnlocked
passiveGame ID 234★★★★
How do you unlock Infestation 2?
Verified starting unlockSource data confirms that no unlock is required.
Spawns allied Blue Spiders from killed enemies.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Infestation 2 leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13