Leprosy
ItemAfterbirth+Locked
passiveGame ID 525★★★★
How do you unlock Leprosy?
In The Binding of Isaac, Leprosy is unlocked by unlocking Leprosy (Achievement).
Structured pathSource-backed requirements are mapped into trackable steps.
Taking damage grants a body part orbital that blocks shots and deals contact damage, up to a maximum of three. The body parts are destroyed after blocking enough damage.
How to unlock: Beat Chapter 3 without taking damage
What unlocking Leprosy leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13