Mama Mega!
ItemAfterbirth+Unlocked
activeGame ID 483★★★★
How do you unlock Mama Mega!?
Verified starting unlockSource data confirms that no unlock is required.
Deals immense damage to all enemies, opens all bombable doors, and destroys all obstacles in the room. The effect occurs every time a new room is entered for the rest of the floor.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Mama Mega! leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13