Mega Blast
ItemAfterbirthLocked
activeGame ID 441★★★★
How do you unlock Mega Blast?
In The Binding of Isaac, Mega Blast is unlocked by unlocking Mega.
Structured pathSource-backed requirements are mapped into trackable steps.
Isaac fires a giant blood laser for approximately 15 seconds. This laser deals massive damage, pushes Isaac backwards, and persists between rooms and floors.
How to unlock: Defeat Mega Satan as every character ([Repentance] except tainted characters)
What unlocking Mega Blast leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13