Mr. ME!
ItemAfterbirth+Locked
activeGame ID 527★★★★
How do you unlock Mr. ME!?
In The Binding of Isaac, Mr. ME! is unlocked by unlocking Mr. ME! (Achievement).
Structured pathSource-backed requirements are mapped into trackable steps.
Summons a controllable ghost that can perform various tasks depending on what it targets.
How to unlock: Open 20 Locked Chests
What unlocking Mr. ME! leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13