Placebo
ItemAfterbirthUnlocked
activeGame ID 348★★★★
How do you unlock Placebo?
Verified starting unlockSource data confirms that no unlock is required.
Copies the effect of the pill currently held by Isaac. [Repentance] The recharge time is based on the power of the pill.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Placebo leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13