Polydactyly
ItemAfterbirth+Unlocked
passiveGame ID 454★★★★
How do you unlock Polydactyly?
Verified starting unlockSource data confirms that no unlock is required.
Allows Isaac to carry two cards, pills, or any combination of both. Spawns one random card, rune, or pill.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Polydactyly leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13