Rune Bag
ItemAfterbirthLocked
familiarGame ID 389★★★★
How do you unlock Rune Bag?
In The Binding of Isaac, Rune Bag is unlocked by earning the Isaac completion mark as Lilith (Character).
Structured pathSource-backed requirements are mapped into trackable steps.
Spawns a familiar that drops a random rune after clearing enough rooms.
See the full unlock path for Rune Bag — 7 stepsWhat unlocking Rune Bag leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13