???'s Only Friend
ItemRebirthLocked
familiarGame ID 320★★★★
How do you unlock ???'s Only Friend?
In The Binding of Isaac, ???'s Only Friend is unlocked by earning the Boss Rush completion mark as ??? (Character).
Structured pathSource-backed requirements are mapped into trackable steps.
Spawns a controllable familiar that deals 37.5 / [Repentance] 15 damage per second on touch. It can be moved using the shooting directional keys
See the full unlock path for ???'s Only Friend — 5 stepsWhat unlocking ???'s Only Friend leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13