Serpent's Kiss

ItemAfterbirthLocked

passiveGame ID 393★★★★

How do you unlock Serpent's Kiss?

In The Binding of Isaac, Serpent's Kiss is unlocked by earning the Satan completion mark as Lilith (Character).

Structured pathSource-backed requirements are mapped into trackable steps.

Tears have a chance to apply a poison effect to enemies. Isaac poisons enemies on contact. Poisoned enemies have a chance to drop a Black Heart when killed.

See the full unlock path for Serpent's Kiss — 7 steps

Serpent's Kiss (Achievement)
- Lilith (Character) → Satan (normal)
  - Lilith (Character)

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What unlocking Serpent's Kiss leads to

Nothing depends on this yet.

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13