The Negative
ItemRebirthLocked
passiveGame ID 328★★★★
How do you unlock The Negative?
In The Binding of Isaac, The Negative is unlocked by unlocking The Negative (Achievement).
Structured pathSource-backed requirements are mapped into trackable steps.
If Isaac has half a red heart or no red hearts after taking damage, all enemies in the room take significant damage. Allows entrance into the Dark Room. [Repentance] +1 Damage and also allows access to Home.
How to unlock: Defeat Satan 5 times
What unlocking The Negative leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13