The Virus
ItemRebirthUnlocked
passiveGame ID 13★★★★
How do you unlock The Virus?
Verified starting unlockSource data confirms that no unlock is required.
Isaac poisons enemies on contact. [Before Repentance] -0.1 speed. [Repentance] +0.2 speed. [Afterbirth before Repentance] Poisoned enemies have a chance to drop a black heart when killed.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking The Virus leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13