The Path to Whore Baby

How to unlock: Don't pick up any hearts for 2 floors in a row

How to reach The Lamb: Defeat Satan 5 times to unlock The Negative. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. Find and defeat The Lamb in Dark Room.

How to reach Mega Satan: ??? or The Lamb must be defeated once for the Golden Gate to spawn. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan.

How to reach Hush: Defeat Mom's Heart for the 10th time to unlock Blue Womb. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. Defeat Hush in Blue Womb.

How to reach Delirium: Defeat Hush to unlock The Void. A Void portal can appear after a major boss; defeating Hush guarantees one. Defeat Delirium, the main boss of The Void.

How to reach Mother: Defeat Hush 3 times to unlock A Secret Exit. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. Collect Knife Piece 1 in Downpour/Dross II. Collect Knife Piece 2 in Mines/Ashpit II. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother.

How to reach The Beast: A Strange Door is unlocked by beating Mother for the first time. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast.