Progression route

The Path to Zodiac

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The path to unlock Zodiac in The Binding of Isaac has 8 steps.

7 requirements remaining11%

Path progress

Paths end with clear instructions for actions that cannot be tracked automatically.

Next steps

Isaac (Character) → The Lamb (normal)
Missing Poster (Achievement)
Missing Poster (Trinket)

Zodiac (Achievement)

The Lost → Ultra Greed

The Lost (Character)

The Lost (Achievement)

All of

Missing Poster (Trinket)

Missing Poster (Achievement)

Isaac → The Lamb

How to reach The Lamb: Defeat Satan 5 times to unlock The Negative. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. Find and defeat The Lamb in Dark Room.

Isaac (Character)

Die in a Sacrifice Room with Missing Poster

React Flow