Progression route

The Path to Lost Soul

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8 requirements remaining10%

Path progress

Paths end with clear instructions for actions that cannot be tracked automatically.

Next steps

Isaac (Character) → The Lamb (normal)
1. Defeat Satan 5 times to unlock The Negative. source
2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
3. Find and defeat The Lamb in Dark Room. source
Missing Poster (Achievement)
Missing Poster (Trinket)

Lost Soul (Item)

Lost Soul (Achievement)

The Lost → Mother

How to reach Mother: Defeat Hush 3 times to unlock A Secret Exit. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. Collect Knife Piece 1 in Downpour/Dross II. Collect Knife Piece 2 in Mines/Ashpit II. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother.

The Lost (Character)

The Lost (Achievement)

All of

Missing Poster (Trinket)

Missing Poster (Achievement)

Isaac → The Lamb

How to reach The Lamb: Defeat Satan 5 times to unlock The Negative. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. Find and defeat The Lamb in Dark Room.

Isaac (Character)

Die in a Sacrifice Room with Missing Poster

React Flow