48 Hour Energy
PillRebirthUnlocked
How do you unlock 48 Hour Energy?
Verified starting unlockSource data confirms that no unlock is required.
Drops one to two Lil' Battery and fully charges the spacebar item. Can be used with x or D1 to generate infinite batteries.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking 48 Hour Energy leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13