Health Down
PillRebirthUnlocked
How do you unlock Health Down?
Verified starting unlockSource data confirms that no unlock is required.
Removes one red heart container. Acts as a Health Up pill if Isaac has one or fewer red heart containers. Characters who cannot have red heart containers will lose one heart.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Health Down leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13