Infested!
PillAfterbirthUnlocked
How do you unlock Infested!?
Verified starting unlockSource data confirms that no unlock is required.
Destroys all poop in the room and spawns a single blue spider under Isaac and on each destroyed poop.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Infested! leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13