Infested?
PillAfterbirthUnlocked
How do you unlock Infested??
Verified starting unlockSource data confirms that no unlock is required.
Spawns blue spiders equal to the number of enemies in the room. If there are no enemies in the room, spawns 1-3 Blue Spiders.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Infested? leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13