One makes you larger
PillAfterbirthUnlocked
How do you unlock One makes you larger?
Verified starting unlockSource data confirms that no unlock is required.
Increases Isaac's size and decreases the pitch of his voice. This effect does not increase the size of Isaac's hitbox, but increases the size of The Forgotten's bone club. These pills contribute to the Stompy transformation.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking One makes you larger leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13