Percs!

PillAfterbirthLocked

How do you unlock Percs!?

In The Binding of Isaac, Percs! is unlocked by unlocking PAY TO PLAY (Challenge).

Structured pathSource-backed requirements are mapped into trackable steps.

For the duration of the room, taking damage only removes a half-heart from Isaac's HP, regardless of the source of the damage. (Similar effect toThe Wafer's)

2 new pills (Achievement)
- PAY TO PLAY (Challenge)
  - PAY TO PLAY (Achievement)
    How to unlock: Defeat Isaac as Cain [before Repentance+] and destroy 10 Tinted Rocks

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What unlocking Percs! leads to

Nothing depends on this yet.

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13