Power Pill!
PillAfterbirthUnlocked
How do you unlock Power Pill!?
Verified starting unlockSource data confirms that no unlock is required.
Temporarily grants invulnerability, inflicts fear on enemies in the room, lets Isaac deal contact damage, and has a chance to replenish a Half Red Heart every time an enemy is killed, similar to The Gamekid.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Power Pill! leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13