Puberty
PillRebirthUnlocked
How do you unlock Puberty?
Verified starting unlockSource data confirms that no unlock is required.
Causes Isaac to grow four hairs from the top of his head and zits on his face. This pill is cosmetic only and will stay for the rest of the run. Consuming three puberty pills will grant the Adult transformation, granting one red heart container and making Isaac's voice slightly deeper (one time effect).
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Puberty leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13