Blank Rune
RuneAfterbirthLocked
How do you unlock Blank Rune?
In The Binding of Isaac, Blank Rune is unlocked by unlocking Blank Rune (Achievement).
Structured pathSource-backed requirements are mapped into trackable steps.
Grants a random rune effect and has a 25% chance to drop another Blank Rune on the ground upon use. Black Rune is excluded.
How to unlock: [before Afterbirth+] Complete Onan's Streak (challenge #29) / [Afterbirth+] Complete The Guardian (challenge #30)
What unlocking Blank Rune leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13