Soul of ???

RuneRepentanceLocked

How do you unlock Soul of ????

In The Binding of Isaac, Soul of ??? is unlocked by earning every normal-mode completion mark as Tainted ???.

Structured pathSource-backed requirements are mapped into trackable steps.

Causes 8 poison farts that leave lingering brown creep, then plants a trail of 7 Butt Bombs in quick succession. Standing on the creep gives +1.5 Fire Rate and +1 Damage.

See the full unlock path for Soul of ??? — 5 steps

Soul of ??? (Achievement)
- All of
  - Tainted ??? → Hush (normal)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Tainted ??? → Boss Rush (normal)

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What unlocking Soul of ??? leads to

Nothing depends on this yet.

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13