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Soul of Azazel

RuneRepentanceLocked

How do you unlock Soul of Azazel?

In The Binding of Isaac, Soul of Azazel is unlocked by earning every normal-mode completion mark as Tainted Azazel.

Structured pathSource-backed requirements are mapped into trackable steps.

Activates Mega Blast for 7.5 seconds.

See the full unlock path for Soul of Azazel — 5 steps

Soul of Azazel (Achievement)
- All of
  - Tainted Azazel → Hush (normal)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Tainted Azazel → Boss Rush (normal)

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What unlocking Soul of Azazel leads to

Nothing depends on this yet.

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13