Die in a Sacrifice Room with Missing Poster

SecretAfterbirthUnlock unknown

How do you unlock Die in a Sacrifice Room with Missing Poster?

Needs researchNo validated unlock requirement has been imported yet.

Die in a Sacrifice Room while holding Missing Poster to unlock The Lost.

This path has not yet been revealed

This requirement hasn't been imported yet.

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What unlocking Die in a Sacrifice Room with Missing Poster leads to

The Lost

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13

The local wiki dump states: The Lost is unlocked by dying in a Sacrifice Room while holding Missing Poster. This action is modeled as a milestone, not as an obtainable room entity.