Callus
TrinketRebirthUnlocked
How do you unlock Callus?
Verified starting unlockSource data confirms that no unlock is required.
Prevents damage from creep and spikes.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Callus leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13