Cursed Skull
TrinketRebirthUnlocked
How do you unlock Cursed Skull?
Verified starting unlockSource data confirms that no unlock is required.
If Isaac has less than one full Red Heart after taking damage, he will be immediately teleported to a random room.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Cursed Skull leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13