Isaac's Head
TrinketRebirthLocked
How do you unlock Isaac's Head?
In The Binding of Isaac, Isaac's Head is unlocked by earning the Boss Rush completion mark as Isaac (Character).
Structured pathSource-backed requirements are mapped into trackable steps.
Spawns Isaac's severed head as a tear-firing familiar. Fires piercing tears.
What unlocking Isaac's Head leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13